Kaempferol Reverses Acute Kidney Injury in Septic Model by Inhibiting NF-κB/AKT Signaling Pathway

Sepsis is the main cause of acute kidney injury (AKI), mainly due to systemic immune dysregulation. Kaempferol (KAE) a natural flavonoid compound with multiple biological activities including anti-inflammatory, antioxidant, and antiapoptotic properties. In this study, we constructed sepsis-induced AKI mouse model an LPS-induced glomerular mesangial cell (HK-2) in vitro sepsis model. We found that KAE ameliorated renal pathological damage, reversed function inhibited p-p65 p-AKT protein expression. addition, proliferation apoptosis HK-2 cells. These studies suggest reverses by inhibiting activation NF-κB/AKT pathway reverse injury.